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Altering SARS Coronavirus Frameshift Efficiency Affects Genomic and Subgenomic RNA Production

In previous studies, differences in the amount of genomic and subgenomic RNA produced by coronaviruses with mutations in the programmed ribosomal frameshift signal of ORF1a/b were observed. It was not clear if these differences were due to changes in genomic sequence, the protein sequence or the fre...

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Hlavní autoři: Ewan P. Plant, Deborah R. Taylor, Jonathan D. Dinman, Ralph S. Baric, Amy C. Sims
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2013-01-01
Edice:Viruses
Témata:
SARS
severe acute respiratory syndrome
pseudoknot
ribosomal frameshifting
viral replication
On-line přístup:http://www.mdpi.com/1999-4915/5/1/279
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