Modular de- and re-construction of vascularized osteochondral tissues in an Organ-on-Chip dual-compartment platform

Background: Homeostasis at the cartilage–bone interface of articular joints depends on tightly orchestrated signalling among chondrocytes, osteogenic progenitors, and subchondral vasculature. Disruption of this crosstalk is considered one of the main drivers of osteoarthritis (OA), the most prevalen...

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Hlavní autoři:	Andrea Mainardi, Andrea Barbero, Martin Ehrbar, Marco Rasponi, Ivan Martin, Paola Occhetta
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-01-01
Edice:	Journal of Orthopaedic Translation
Témata:	Organs-on-chip In vitro model Osteoarthritis Bone-cartilage interface Vascularization Bottom-up approach
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2214031X2500172X
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