Critical role of the CMGC insert sequence for tyrosine autophosphorylation in the protein kinase DYRK1B

Abstract Many CMGC group kinases require phosphorylation of a conserved tyrosine residue in the activation loop to achieve catalytic activity. DYRK family members use a distinctive mechanism involving constitutive cis-autophosphorylation of this tyrosine. The structural basis of this process has rem...

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Autors principals:	Silvia Detro-Dassen, Katharina Schwandt, Philip Helmich, Stefan Düsterhöft, Walter Becker
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-12-01
Col·lecció:	Scientific Reports
Matèries:	DYRK1A DYRK1B Kinase domain Autophosphorylation CMGC insert AOMS3
Accés en línia:	https://doi.org/10.1038/s41598-025-33562-x
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