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The role of large immune complexes in anti-drug antibody development: a case study of anti-SARS-CoV-2 antibody therapeutics and co-administered mRNA vaccine

The administration of therapeutic proteins may induce an anti-drug antibody (ADA) response which may impact pharmacokinetics, safety or efficacy. Numerous factors contribute to ADA development, such as patient population, drug sequence, formulation impurities, as well as drug dose and frequency. Her...

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Kaydedildi:
Asıl Yazarlar: Susan C. Irvin, Zhiqiang Wang, Samit Ganguly, Deepanshu Choudhary, Minita Kanagaraj, Nina Liu, Flonza Isa, Zhongqing Will He, Hong Yan, Veronica Mas Casullo, Kenneth C. Turner, John D. Davis, Michael P. Rosconi, Albert Torri, Michael A. Partridge
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2026-03-01
Seri Bilgileri:Frontiers in Immunology
Konular:
anti-drug antibodies
COVID-19
immune complex
immunogenicity
monoclonal antibodies
Online Erişim:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1769163/full
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