Ex vivo mass spectrometry-based biodistribution analysis of an antibody-Resiquimod conjugate bearing a protease-cleavable and acid-labile linker

Immune-stimulating antibody conjugates (ISACs) equipped with imidazoquinoline (IMD) payloads can stimulate endogenous immune cells to kill cancer cells, ultimately inducing long-lasting anticancer effects. A novel ISAC was designed, featuring the IMD Resiquimod (R848), a tumor-targeting antibody spe...

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Главные авторы:	Lydia Bisbal Lopez, Domenico Ravazza, Matilde Bocci, Aureliano Zana, Lucrezia Principi, Sheila Dakhel Plaza, Andrea Galbiati, Ettore Gilardoni, Jörg Scheuermann, Dario Neri, Luca Pignataro, Cesare Gennari, Samuele Cazzamalli, Alberto Dal Corso
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2023-12-01
Серии:	Frontiers in Pharmacology
Предметы:	immune stimulating antibody conjugates Resiquimod toll-like receptors prodrugs quantitative biodistribution
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1320524/full
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