Desipramine treatment disrupts phagocytic and intracellular survival of Brucella abortus 544 in RAW 264.7 cells and promotes bacterial resistance with enhanced immune responses in ICR mice

IntroductionBrucella (B.) abortus is an intracellular pathogen that causes chronic infection and remains difficult to treat. In this study, desipramine (DMI) was investigated as a potential host-directed therapeutic strategy to control Brucella infection.MethodsThe effects of DMI on B. abortus infec...

Полное описание

Библиографические подробности

Главные авторы:	Tran Xuan Ngoc Huy, Said Abdi Salad, Trang Thi Nguyen, Ched Nicole Turbela Aguilar, Eoin Quiatchon Lajara, Wongi Min, Hu Jang Lee, Alisha Wehdnesday Bernardo Reyes, Suk Kim
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2026-05-01
Серии:	Frontiers in Veterinary Science
Предметы:	Brucella abortus desipramine ICR mouse internalization intracellular growth pro-inflammatory cytokines
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fvets.2026.1779164/full
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