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Host–Guest Interaction Study of Olmesartan Medoxomil with β-Cyclodextrin Derivatives

Olmesartan medoxomil (OLM) is a selective angiotensin II receptor antagonist used in the treatment of hypertension. Its therapeutic potential is limited by its poor water solubility, leading to poor bioavailability. Encapsulation of the drug substance by two methylated cyclodextrins, namely randomly...

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Principais autores: Minodora Andor, Claudia Temereancă, Laura Sbârcea, Adriana Ledeți, Dana Emilia Man, Cristian Mornoș, Amalia Ridichie, Denisa Cîrcioban, Gabriela Vlase, Paul Barvinschi, Angela Caunii, Renata-Maria Văruţ, Cristina Maria Trandafirescu, Valentina Buda, Ionuț Ledeți, Matilda Rădulescu
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-05-01
Serier:Molecules
Fag:
olmesartan medoxomil
cyclodextrins
inclusion complex
molecular encapsulation
solubility enhancement
spectroscopic methods
Online adgang:https://www.mdpi.com/1420-3049/29/10/2209
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