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LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival

<p>Abstract</p> <p>Background</p> <p>We recently showed that LOH proximal to <it>M6P/IGF2R</it> locus (<it>D6S1581</it>) in primary ovarian tumors is predictive for the presence of disseminated tumor cells (DTC) in the bone marrow (BM). For therapy-monitoring, it would be highly desirable to establi...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Kuhlmann Jan, Schwarzenbach Heidi, Wimberger Pauline, Poetsch Micaela, Kimmig Rainer, Kasimir-Bauer Sabine
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2012-07-01
Schriftenreihe:BMC Cancer
Schlagworte:
Circulating DNA
Loss of heterozygosity
Disseminated tumor cells
DNA-fractionation
Tumor suppressor genes
Online-Zugang:http://www.biomedcentral.com/1471-2407/12/325
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