A familial Alzheimer's disease associated mutation in presenilin-1 mediates amyloid-beta independent cell specific neurodegeneration.

Mutations in the presenilin (PS) genes are a predominant cause of familial Alzheimer's disease (fAD). An ortholog of PS in the genetic model organism Caenorhabditis elegans (C. elegans) is sel-12. Mutations in the presenilin genes are commonly thought to lead to fAD by upregulating the expression of...

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Detalhes bibliográficos

Principais autores:	Mahraz Parvand, Joseph J H Liang, Tahereh Bozorgmehr, Dawson Born, Alvaro Luna Cortes, Catharine H Rankin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2024-01-01
coleção:	PLoS ONE
Acesso em linha:	https://doi.org/10.1371/journal.pone.0289435
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