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Spastin's microtubule-binding properties and comparison to katanin.

Spastin and katanin are ring-shaped hexameric AAA ATPases that sever microtubules, and thus crucially depend on a physical interaction with microtubules. For the first time, we report here the microtubule binding properties of spastin at the single-molecule level, and compare them to katanin. Micros...

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Autores principales: Thomas Eckert, Doan Tuong-Van Le, Susanne Link, Lena Friedmann, Günther Woehlke
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2012-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC3521757?pdf=render
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