A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda

Evolutionary theory hypothesizes that intermediate virulence maximizes pathogen fitness as a result of a trade-off between virulence and transmission, but empirical evidence remains scarce. We bridge this gap using data from a large and long-standing HIV-1 prospective cohort, in Uganda. We use an ep...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	François Blanquart, Mary Kate Grabowski, Joshua Herbeck, Fred Nalugoda, David Serwadda, Michael A Eller, Merlin L Robb, Ronald Gray, Godfrey Kigozi, Oliver Laeyendecker, Katrina A Lythgoe, Gertrude Nakigozi, Thomas C Quinn, Steven J Reynolds, Maria J Wawer, Christophe Fraser
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	eLife Sciences Publications Ltd 2016-11-01
Σειρά:	eLife
Θέματα:	viral evolution transmission-virulence trade-off adaptation quantitative genetics selection
Διαθέσιμο Online:	https://elifesciences.org/articles/20492
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