Lung-Targeted Transgene Expression of Nanocomplexed Ad5 Enhances Immune Response in the Presence of Preexisting Immunity

Recombinant adenovirus serotype 5 (Ad5) vector has been widely applied in vaccine development targeting infectious diseases, such as Ebola virus disease and coronavirus disease 2019 (COVID-19). However, the high prevalence of preexisting anti-vector immunity compromises the immunogenicity of Ad5-bas...

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Autores principales:	Yilong Yang, Shipo Wu, Yudong Wang, Fangze Shao, Peng Lv, Ruihua Li, Xiaofan Zhao, Jun Zhang, Xiaopeng Zhang, Jianmin Li, Lihua Hou, Junjie Xu, Wei Chen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2023-08-01
Colección:	Engineering
Materias:	Adenovirus serotype 5 Vaccine Preexisting immunity Nanoparticles Transgene expression
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2095809923000103
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