Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition

Abstract Endometrial cancer (EC) patients with metastatic/recurrent disease have limited treatment options and poor survival outcomes. Recently, we discovered the FGFR2c splice isoform is associated with poor prognosis in EC patients. Here we report the establishment of 16 EC patient-derived xenogra...

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Detalhes bibliográficos

Principais autores:	Asmerom T. Sengal, Vanessa Bonazzi, Deborah Smith, Cristian P. Moiola, Rohan Lourie, Rebecca Rogers, Eva Colas, Antonio Gil-Moreno, Sophia Frentzas, Naven Chetty, Lewis Perrin, Pamela M. Pollock
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2023-12-01
coleção:	npj Precision Oncology
Acesso em linha:	https://doi.org/10.1038/s41698-023-00478-6
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