Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes

Basigin is an essential host receptor for invasion of Plasmodium falciparum into human erythrocytes, interacting with parasite surface protein PfRH5. PfRH5 is a leading blood-stage malaria vaccine candidate and a target of growth-inhibitory antibodies. Here, we show that erythrocyte basigin is exclu...

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Hlavní autoři:	Abhishek Jamwal, Cristina F Constantin, Stephan Hirschi, Sebastian Henrich, Wolfgang Bildl, Bernd Fakler, Simon J Draper, Uwe Schulte, Matthew K Higgins
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2023-10-01
Edice:	eLife
Témata:	PfRH5 basigin monoclonal antibody PMCA MCT1 malaria
On-line přístup:	https://elifesciences.org/articles/83681
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