High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy

Abstract The pathophysiology of epilepsy underlies a complex network dysfunction between neurons and glia, the molecular cell type-specific contributions of which remain poorly defined in the human disease. In this study, we validated a method that simultaneously isolates neuronal (NEUN +), astrocyt...

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Detalhes bibliográficos

Principais autores:	Balagopal Pai, Jessica Tome-Garcia, Wan Sze Cheng, German Nudelman, Kristin G. Beaumont, Saadi Ghatan, Fedor Panov, Elodia Caballero, Kwadwo Sarpong, Lara Marcuse, Jiyeoun Yoo, Yan Jiang, Anne Schaefer, Schahram Akbarian, Robert Sebra, Dalila Pinto, Elena Zaslavsky, Nadejda M. Tsankova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-10-01
coleção:	Acta Neuropathologica Communications
Acesso em linha:	https://doi.org/10.1186/s40478-022-01453-1
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