B7 homolog 3-targeted CAR-T cells secreting EGFR T-cell engagers for improved control of glioblastoma progression

Abstract Glioblastoma (GBM) is the most aggressive primary malignant brain tumor, and while chimeric antigen receptor-T (CAR-T) cell therapy has shown promise, its efficacy remains limited by antigen heterogeneity and immune escape. Here, we investigated the expression of B7 homolog 3 (B7-H3), epide...

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Bibliografiske detaljer

Principais autores:	Zongliang Zhang, Nian Yang, Hui Zeng, Yongdong Chen, Huaqing Lu, Long Xu, Zeng Wang, Guoqing Wang, Liangxue Zhou, Aiping Tong
Format:	Artigo
Sprog:	Inglês
Udgivet:	Springer 2026-06-01
Serier:	Molecular Biomedicine
Fag:	GBM CAR-T Bispecific T-cell engager B7-H3 EGFR
Online adgang:	https://doi.org/10.1186/s43556-026-00492-7
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