Dap10 co-stimulation enhances the anti-HCC efficacy of NKp30 chimeric antigen receptor T cells

Chimeric antigen receptor (CAR) T-cell immunotherapy has made significant breakthroughs in the treatment of relapsed or refractory hematologic malignancies, but its efficacy in solid tumors remains limited. In this study, we developed a chimeric NKp30 (chNKp30) receptor whose ligand, B7H6, is often...

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Autors principals:	JieYu Li, LiMei Chen, MingShui Chen, Miao Lin, Zineng Xie, HuiLing Wu, ZhiFeng Zhou, WanSong Lin
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-07-01
Col·lecció:	Translational Oncology
Matèries:	DAP 10 signaling domain Chimeric antigen receptor (CAR) NKP30 Hepatocellular carcinoma
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1936523325001561
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