Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership

After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of drug discovery for HAT with special emphasis on the discovery, pre-clinical development, and operational challenge...

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Autors principals:	Sonja Bernhard, Marcel Kaiser, Christian Burri, Pascal Mäser
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-10-01
Col·lecció:	Diseases
Matèries:	human African trypanosomiasis sleeping sickness <i>Trypanosoma brucei</i> drug discovery nitroimidazole product development partnership
Accés en línia:	https://www.mdpi.com/2079-9721/10/4/90
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