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Population pharmacokinetics, exposure-safety, and immunogenicity of atezolizumab in pediatric and young adult patients with cancer

Abstract Background The iMATRIX-atezolizumab study was a phase I/II, multicenter, open-label study designed to assess the safety and pharmacokinetics of atezolizumab in pediatric and young adult patients. We describe the pharmacokinetics (PK), exposure-safety, and immunogenicity of atezolizumab in p...

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Principais autores: Colby S. Shemesh, Pascal Chanu, Kris Jamsen, Russ Wada, Gianluca Rossato, Francis Donaldson, Amit Garg, Helen Winter, Jane Ruppel, Xin Wang, Rene Bruno, Jin Jin, Sandhya Girish
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2019-11-01
Series:Journal for ImmunoTherapy of Cancer
Assuntos:
Atezolizumab
Cancer immunotherapy
Clinical pharmacology
Exposure-safety
Immune checkpoint inhibitor
Pediatric oncology
Acceso en liña:http://link.springer.com/article/10.1186/s40425-019-0791-x
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