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1,3,4-Oxadiazole and 1,3,4-Thiadiazole Nortopsentin Derivatives against Pancreatic Ductal Adenocarcinoma: Synthesis, Cytotoxic Activity, and Inhibition of CDK1

A new series of nortopsentin analogs, in which the central imidazole ring of the natural lead was replaced by a 1,3,4-oxadiazole or 1,3,4-thiadiazole moiety, was efficiently synthesized. The antiproliferative activity of all synthesized derivatives was evaluated against five pancreatic ductal adenoc...

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Principais autores: Daniela Carbone, Camilla Pecoraro, Giovanna Panzeca, Geng Xu, Margot S. F. Roeten, Stella Cascioferro, Elisa Giovannetti, Patrizia Diana, Barbara Parrino
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-07-01
Serier:Marine Drugs
Fag:
1,3,4-oxadiazole
1,3,4-thiadiazole
nortopsentin analogs
inhibition of migration
PDAC antiproliferative activity
inhibition of CDK1 expression
Online adgang:https://www.mdpi.com/1660-3397/21/7/412
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