Paternal Sertoli cell-derived extracellular vesicles transfer mtDNA and microRNA cargo to trigger germ cell oxidative stress and induce metabolic risks in offspring

Abstract While obesity causes male infertility through testicular lipid stress, the mechanisms by which this stress alters Sertoli cell-derived extracellular vesicles (EVs) to induce paternal reproductive defects and offspring metabolic dysfunction remain unclear. Here, we report that lipid-overload...

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Detalhes bibliográficos

Principais autores:	Jingxian Deng, Lu Li, Zhuoying Huang, Xi Wei, Xiaorui Zhang, Sutong Hua, Jiawei Hao, Yanze Zhang, Yuwei Fu, Xuanzhe Cao, Yan Yang, Yadong Huang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-05-01
coleção:	Cell Communication and Signaling
Assuntos:	Lipid metabolism Sertoli cells Extracellular vesicles Mitochondria Oxidative stress
Acesso em linha:	https://doi.org/10.1186/s12964-026-02889-x
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