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Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation

Abstract Background Apo- (iron free) and holo- (iron bound) transferrin (Tf) participate in precise regulation of brain iron uptake at endothelial cells of the blood–brain barrier. Apo-Tf indicates an iron-deficient environment and stimulates iron release, while holo-Tf indicates an iron sufficient...

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Principais autores: Stephanie L. Baringer, Kondaiah Palsa, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-06-01
Serier:Journal of Biomedical Science
Fag:
Blood–brain barrier
Iron
Transferrin
Hepcidin
Ferroportin
Hephaestin
Online adgang:https://doi.org/10.1186/s12929-023-00934-2
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