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Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a

Planar cell polarity (PCP) signaling plays a critical role in tissue morphogenesis. In mammals, disruption of three of the six “core PCP” components results in polarity-dependent defects with rotated cochlear hair cell stereocilia and open neural tube. We recently demonstrated a role of Prickle1, a...

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Principais autores: Chunqiao Liu, Chen Lin, Chun Gao, Helen May-Simera, Anand Swaroop, Tiansen Li
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2014-09-01
Serier:Biology Open
Fag:
Planar cell polarity
Development
Morphogenesis
Organogenesis
Conditional mouse mutants
Online adgang:http://bio.biologists.org/content/3/9/861
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