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Heme oxygenase-1 protects cells from replication stress

Heme oxygenase-1 (HO-1, HMOX1) degrades heme protecting cells from heme-induced oxidative damage. Beyond its well-established cellular functions, heme has emerged as a stabilizer of G-quadruplexes. These secondary DNA structures interfere with DNA replication. We recently revealed that nuclear HO-1...

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Principais autores: Patryk Chudy, Jakub Kochan, Mateusz Wawro, Phu Nguyen, Monika Gorczyca, Aliaksandra Varanko, Aleksandra Retka, Swati Sweta Ghadei, Emilija Napieralska, Anna Grochot-Przęczek, Krzysztof Szade, Lea-Sophie Berendes, Julien Park, Grzegorz Sokołowski, Qiuliyang Yu, Alicja Józkowicz, Witold N. Nowak, Wojciech Krzeptowski
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-09-01
coleção:Redox Biology
Assuntos:
Heme oxygenase-1
Heme
Replication stress
G-quadruplexes
PARP1
Cell cycle
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231724002258
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