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Isosativan from the Nigerian Propolis Activates the mTORC2/AKT Pathway and Suppresses Muscle Atrophy Genes Atrogin-1 and MuRF1 in Diabetic Rats

Objective: The study investigated the effects of Isosativan on the mTORC2/AKT pathway and diabetic muscle atrophy in a rat model of the disease. Material and Methods: Diabetes was induced by a high-fat diet and administration of a low-dose streptozotocin injection. The animals confirmed to be diabet...

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Principais autores: Mustafa Ibrahim Oladayo, Jimoh Lukman, Imam Abubakar Lekan, Ahmmed Bayo Opalekunde
Formato: Artigo
Idioma:Inglês
Publicado em: Prince of Songkla University 2025-11-01
coleção:Journal of Health Science and Medical Research (JHSMR)
Assuntos:
diabetes mellitus
isosativan
muscle atrophy
mtorc2/akt pathway
nigerian propolis
Acesso em linha:https://www.jhsmr.org/index.php/jhsmr/article/view/1195
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