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Structure-Guided Identification of JAK2 Inhibitors: From Similarity to Stability and Specificity

<b>Background/Objectives</b>: Janus kinase 2 (JAK2) is a pivotal signaling protein implicated in various hematological malignancies and inflammatory disorders, making it a compelling target for therapeutic intervention. <b>Methods</b>: In this study, we employed an integrative computational approach...

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Principais autores: Muhammad Yasir, Jinyoung Park, Jongseon Choe, Jin-Hee Han, Eun-Taek Han, Won Sun Park, Wanjoo Chun
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-11-01
coleção:Future Pharmacology
Assuntos:
JAK2 selective inhibitors
JAK/STAT pathway
molecular dynamics simulation
molecular docking
promising JAK2 drug candidates
Acesso em linha:https://www.mdpi.com/2673-9879/5/4/66
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