Efflux pump blockers in Gram-negative bacteria:The new generation of hydantoin based-modulators to improve antibiotic activity

Multidrug resistant (MDR) bacteria are an increasing health problem with the shortage of new active antibiotic agents. Among effective mechanisms that contribute to the spread of MDR Gram-negative bacteria are drug efflux pumps that expel clinically important antibiotic classes out of the cell. Drug...

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Autors principals:	Ewa eOtrębska-Machaj, Jacqueline eChevalier, Jadwiga eHandzlik, Ewa eSzymańska, Jakub eSchabikowski, Gérard eBoyer, Jean-Michel eBolla, Katarzyna eKieć-Kononowicz, Jean-Marie ePAGES, Sandrine eAlibert
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2016-05-01
Col·lecció:	Frontiers in Microbiology
Matèries:	Hydantoins antibiotics Multidrug resistance efflux pumps AcrAB pump Efflux pump blocker
Accés en línia:	http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00622/full
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