Lysine 2-hydroxyisobutyrylation of HXK1 alters energy metabolism and KATP channel function in the atrium from patients with atrial fibrillation

Abstract Background Atrial fibrillation (AF) is the most common form of arrhythmia and is a growing clinical problem. Post-translational modifications (PTMs) constitute crucial epigenetic mechanisms but modification of lysine 2-hydroxyisobutyrylation (Khib) in AF is still unknown. This study aimed t...

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Detalhes bibliográficos

Principais autores:	Hai-Tao Hou, Xiang-Chong Wang, Huan-Xin Chen, Jun Wang, Qin Yang, Guo-Wei He
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-03-01
coleção:	Cell Communication and Signaling
Assuntos:	Atrial fibrillation Catalysis 2-hydroxyisobutyrylation Post-translational modification Acylation
Acesso em linha:	https://doi.org/10.1186/s12964-025-02108-z
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