HiPSC-derived cardiomyocyte to model Brugada syndrome: both asymptomatic and symptomatic mutation carriers reveal increased arrhythmogenicity

Abstract Brugada syndrome is an inherited cardiac arrhythmia disorder that is mainly associated with mutations of the cardiac voltage-gated sodium channel alpha subunit 5 (SCN5A) gene. The clinical symptoms include ventricular fibrillation and an increased risk of sudden cardiac death. Human-induced...

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Hauptverfasser:	Kirsi Penttinen, Chandra Prajapati, Disheet Shah, Dhanesh Kattipparambil Rajan, Reeja Maria Cherian, Heikki Swan, Katriina Aalto-Setälä
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2023-04-01
Schriftenreihe:	BMC Cardiovascular Disorders
Schlagworte:	Brugada syndrome Human-induced pluripotent stem cell derived cardiomyocyte Sodium SCN5A Arrhythmia
Online-Zugang:	https://doi.org/10.1186/s12872-023-03234-7
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