MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.
During gametogenesis and pre-implantation development, the mammalian epigenome is reprogrammed to establish pluripotency in the epiblast. Here we show that the histone 3 lysine 4 (H3K4) methyltransferase, MLL2, controls most of the promoter-specific chromatin modification, H3K4me3, during oogenesis...
محفوظ في:
| المؤلفون الرئيسيون: | , , , , , , |
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| التنسيق: | Artigo |
| اللغة: | Inglês |
| منشور في: |
Public Library of Science (PLoS)
2010-08-01
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| سلاسل: | PLoS Biology |
| الوصول للمادة أونلاين: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808952/?tool=EBI |
| الوسوم: |
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