Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disease characterized by progressive degeneration of upper and lower motor neurons. As with the majority of neurodegenerative diseases, the pathological hallmarks of ALS involve proteinopathies which lead to the formation o...

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Principais autores:	Bridget C. Benson, Pamela J. Shaw, Mimoun Azzouz, J. Robin Highley, Guillaume M. Hautbergue
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-12-01
coleção:	Frontiers in Neuroscience
Assuntos:	proteinopathies RNA metabolism alteration mitochondrial dysfunction impaired proteostasis amyotrophic lateral sclerosis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2021.783624/full
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