Elevated levels of Letm1 drives mitochondrial dysfunction and cardiomyocyte stress-mediated apoptosis in cultured cardiomyocytes

Abstract Background Cardiac ischemia, a predominant cause of heart failure, is marked by profound mitochondrial dysfunction, dysregulated ion homeostasis, and maladaptive cellular remodeling, all of which compromise cardiac performance. The mitochondrial inner membrane protein Leucine zipper-EF-hand...

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Principais autores:	Anushka Deshpande, Leo Weirauch, Tapan Kumar Baral, Marco Steier, Ankush Borlepawar, Manju Kumari, Lucia S. Kilian, Karsten Richter, Elke Hammer, Derk Frank, Constanze Schmidt, Norbert Frey, Ashraf Y. Rangrez
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2025-08-01
Series:	Cell Communication and Signaling
Assuntos:	Letm1 Mitochondrial metabolism Cardiomyocytes Hypertrophy Arrhythmias
Acceso en liña:	https://doi.org/10.1186/s12964-025-02378-7
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