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ADAM9 drives PD-L1 shedding via IL-6 suppression and exploring therapeutic role of Bufalin treatment in hepatocellular carcinoma

Abstract The treatment landscape for advanced hepatocellular carcinoma (HCC) has changed significantly with the recent introduction of immunotherapy, particularly immune checkpoint inhibitors (ICIs), such as those for programmed cell death ligand 1 (PD-L1). However, the heterogeneous response to ICI...

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Bibliografische gegevens
Hoofdauteurs: Mandana AmeliMojarad, Melika AmeliMojarad, Alireza Pourmahdian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer 2025-10-01
Reeks:Discover Oncology
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Online toegang:https://doi.org/10.1007/s12672-025-03522-y
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