6’-Fluoro[4.3.0]bicyclo nucleic acid: synthesis, biophysical properties and molecular dynamics simulations

Here we report on the synthesis, biophysical properties and molecular modeling of oligonucleotides containing unsaturated 6’-fluoro[4.3.0]bicyclo nucleotides (6’F-bc4,3-DNA). Two 6’F-bc4,3 phosphoramidite building blocks (T and C) were synthesized starting from a previously described [3.3.0]bicyclic...

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Detalhes bibliográficos

Principais autores:	Sibylle Frei, Andrei Istrate, Christian J. Leumann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Beilstein-Institut 2018-12-01
coleção:	Beilstein Journal of Organic Chemistry
Assuntos:	DNA/RNA affinity fluorinated cyclopropanes fluorinated nucleic acids molecular dynamics simulations sugar modified nucleosides
Acesso em linha:	https://doi.org/10.3762/bjoc.14.288
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