Hypothalamic atrophy in primary lateral sclerosis, assessed by convolutional neural network-based automatic segmentation

Abstract Primary lateral sclerosis (PLS) is a motor neuron disease (MND) which mainly affects upper motor neurons. Within the MND spectrum, PLS is much more slowly progressive than amyotrophic laterals sclerosis (ALS). `Classical` ALS is characterized by catabolism and abnormal energy metabolism pre...

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Autores principales:	Jan Kassubek, Francesco Roselli, Simon Witzel, Johannes Dorst, Albert C. Ludolph, Volker Rasche, Ina Vernikouskaya, Hans-Peter Müller
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-01-01
Colección:	Scientific Reports
Materias:	Hypothalamus Neuronal Networks Metabolism Magnetic Resonance Imaging Volumetry Amyotrophic Lateral Sclerosis
Acceso en línea:	https://doi.org/10.1038/s41598-025-85786-6
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