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Sulfated dextrans enhance in vitro amplification of bovine spongiform encephalopathy PrP(Sc) and enable ultrasensitive detection of bovine PrP(Sc).

Prions, infectious agents associated with prion diseases such as Creutzfeldt-Jakob disease in humans, bovine spongiform encephalopathy (BSE) in cattle, and scrapie in sheep and goats, are primarily comprised of PrP(Sc), a protease-resistant misfolded isoform of the cellular prion protein PrP(C). Pro...

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Principais autores: Yuichi Murayama, Miyako Yoshioka, Kentaro Masujin, Hiroyuki Okada, Yoshifumi Iwamaru, Morikazu Imamura, Yuichi Matsuura, Shigeo Fukuda, Sadao Onoe, Takashi Yokoyama, Shirou Mohri
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2010-10-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC2949392?pdf=render
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