Repurposed clindamycin suppresses pyroptosis in tumor-associated macrophages through Inhibition of caspase-1

Abstract Background The metastatic microenvironment is often rich in tumor-associated macrophages (TAMs). In uveal melanoma (UM), high levels of TAMs positively correlate with tumor progression and poorer prognosis. We hypothesize that the immunomodulation of TAMs can remodel the UM tumor microenvir...

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Detalhes bibliográficos

Principais autores:	Adrian Weich, Johannes Berges, Cindy Flamann, Katrin Bitterer, Krishna Pal Singh, David Chambers, Christopher Lischer, Xin Lai, Olaf Wolkenhauer, Carola Berking, Gerhard Krönke, Shailendra Gupta, Heiko Bruns, Julio Vera, Research Group Macrophages
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-08-01
coleção:	Journal of Experimental & Clinical Cancer Research
Acesso em linha:	https://doi.org/10.1186/s13046-025-03478-5
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