Intra-patient stability of tumor mutational burden from tissue biopsies at different time points in advanced cancers

Abstract Background Tumor mutational burden (TMB) may be a predictive biomarker of immune checkpoint inhibitor (ICI) responsiveness. Genomic landscape heterogeneity is a well-established cancer feature. Molecular characteristics may differ even within the same tumor specimen and undoubtedly evolve w...

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Principais autores:	Timothy V. Pham, Aaron M. Goodman, Smruthy Sivakumar, Garrett Frampton, Razelle Kurzrock
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2021-10-01
Serija:	Genome Medicine
Teme:	Tumor mutational burden Immunotherapy Immunotherapy effect on TMB TMB over time TMB over treatment
Online dostop:	https://doi.org/10.1186/s13073-021-00979-8
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