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Detoxification of methylglyoxal by the glyoxalase system is required for glutathione availability and virulence activation in Listeria monocytogenes.

Listeria monocytogenes is a Gram-positive, food-borne pathogen that lives a biphasic lifestyle, cycling between the environment and as a facultative intracellular pathogen of mammals. Upon entry into host cells, L. monocytogenes upregulates expression of glutathione synthase (GshF) and its product,...

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Autores principales: Andrea Anaya-Sanchez, Ying Feng, John C Berude, Daniel A Portnoy
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2021-08-01
Colección:PLoS Pathogens
Acceso en línea:https://doi.org/10.1371/journal.ppat.1009819
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