Structural Based Analyses of the JC Virus T-Antigen F258L Mutant Provides Evidence for DNA Dependent Conformational Changes in the C-Termini of Polyomavirus Origin Binding Domains.

The replication of human polyomavirus JCV, which causes Progressive Multifocal Leukoencephalopathy, is initiated by the virally encoded T-antigen (T-ag). The structure of the JC virus T-ag origin-binding domain (OBD) was recently solved by X-ray crystallography. This structure revealed that the OBD...

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Автори:	Gretchen Meinke, Paul J Phelan, Jong Shin, David Gagnon, Jacques Archambault, Andrew Bohm, Peter A Bullock
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Public Library of Science (PLoS) 2016-01-01
Серія:	PLoS Pathogens
Онлайн доступ:	https://doi.org/10.1371/journal.ppat.1005362
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