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Cellular senescence-driven transcriptional reprogramming of the MAFB/NOTCH3 axis activates the PI3K/AKT pathway and promotes osteosarcoma progression

Osteosarcoma is the most common primary malignancy of bones and primarily occurs in adolescents and young adults. However, a second smaller peak of osteosarcoma incidence was reported in the elderly aged more than 60. Elderly patients with osteosarcoma exhibit different characteristics compared to y...

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Principais autores: Zhenhao Zhang, Doudou Jing, Baijun Xuan, Zhicai Zhang, Wei Wu, Zengwu Shao
Formato: Artigo
Idioma:Inglês
Publicado: KeAi Communications Co., Ltd. 2024-03-01
Series:Genes and Diseases
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Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2352304223000806
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