Deficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation

Abstract Background There are two isoforms of sphingomyelin synthase (SMS): SMS1 and SMS2. SMS1 is located in the Golgi apparatus only while SMS2 is located in both the plasma membrane and the Golgi apparatus. SMS1 and SMS2 act similarly to generate sphingomyelin (SM). We have undertaken the experim...

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Autores principales:	Goichi Matsumoto, Chieko Hashizume, Ken Watanabe, Makoto Taniguchi, Toshiro Okazaki
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2019-12-01
Colección:	Molecular Medicine
Materias:	Sphingomyelin synthase 1 Sphingomyelin synthase 2 SP7 Osteoblast differentiation Bone morphogenic protein 2 Smad1/5/8
Acceso en línea:	https://doi.org/10.1186/s10020-019-0123-0
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