The regulation and pharmacological modulation of immune complex induced type III IFN production by plasmacytoid dendritic cells

Abstract Objective Patients with systemic lupus erythematosus (SLE) have an ongoing interferon (IFN) production due to an activation of plasmacytoid dendritic cells (pDCs), which can be triggered to type I IFN synthesis by RNA containing immune complexes (RNA-IC). Considering emerging data suggestin...

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Hlavní autoři:	Karin Hjorton, Niklas Hagberg, Pascal Pucholt, Maija-Leena Eloranta, Lars Rönnblom
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2020-06-01
Edice:	Arthritis Research & Therapy
Témata:	SLE IFN pDC NK HCQ IRAK4
On-line přístup:	http://link.springer.com/article/10.1186/s13075-020-02186-z
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