Mechanistic in vitro–in vivo extrapolation (IVIVE) approach using a biomimetic in vitro system for the prediction of hepatic clearance

This study proposes a novel in vitro–in vivo extrapolation (IVIVE) strategy that integrates a patented biomimetic in vitro system with pharmacokinetic modeling to improve the prediction of in vivo drug kinetics. The system employed a single-well plate design with various sizes of mesh inserts to sim...

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Egile Nagusiak:	Seongwon Park, Sun-Sook Song, Woojin Jung, Hwi-yeol Yun, Soyoung Lee, Sun-Woong Kang, Jung-Woo Chae
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2025-01-01
Saila:	Computational and Structural Biotechnology Journal
Gaiak:	3 R principle Biomimetic in vitro system In vitro–in vivo extrapolation (IVIVE) Pharmacokinetic model HepaRG cell
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2001037025002004
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