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Studies of liver tissue identify functional gene regulatory elements associated to gene expression, type 2 diabetes, and other metabolic diseases

Abstract Background Genome-wide association studies (GWAS) of diseases and traits have found associations to gene regions but not the functional SNP or the gene mediating the effect. Difference in gene regulatory signals can be detected using chromatin immunoprecipitation and next-gen sequencing (Ch...

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Hlavní autoři: Marco Cavalli, Nicholas Baltzer, Gang Pan, José Ramón Bárcenas Walls, Karolina Smolinska Garbulowska, Chanchal Kumar, Stanko Skrtic, Jan Komorowski, Claes Wadelius
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2019-04-01
Edice:Human Genomics
Témata:
ChIP-seq
T2D
Regulatory SNPs
On-line přístup:http://link.springer.com/article/10.1186/s40246-019-0204-8
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