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NKG2D blockade impairs tissue-resident memory T cell accumulation and reduces chronic lung allograft dysfunction

Chronic lung allograft dysfunction (CLAD) substantially limits long-term survival following lung transplantation. To identify potential targets for CLAD prevention, T cells from explanted CLAD lungs and lung-draining lymph nodes, as well as diseased and nondiseased controls were isolated and single-...

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Principais autores: Kaveh Moghbeli, Madeline A. Lipp, Marta Bueno, Andrew Craig, Michelle Rojas, Minahal Abbas, Zachary I. Lakkis, Byron Chuan, John Sembrat, Kentaro Noda, Daniel J. Kass, Kong Chen, Li Fan, Tim Oury, Zihe Zhou, Xingan Wang, John F. McDyer, Oliver Eickelberg, Mark E. Snyder
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical investigation 2025-02-01
coleção:JCI Insight
Assuntos:
Immunology
Transplantation
Acesso em linha:https://doi.org/10.1172/jci.insight.184048
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