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Induction of moderate DNA damage enhances megakaryopoiesis and platelet production

Abstract: Megakaryocytes (MKs) are large, hematopoietic cells with a polyploid, multilobulated nucleus. Although DNA replication in MKs (endomitosis) is well studied, limited investigations have examined the impact of DNA instability on megakaryopoiesis. Poly–adenosine diphosphate (ADP) ribose polym...

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Autori principali: Virginia Camacho, Roelof H. Bekendam, Andrew P. Stone, Maria N. Barrachina, Siobhan Branfield, Estelle Carminita, Isabelle C. Becker, Dong H. Lee, Ethan Walsey, Clementine Payne, Jakub Kaplan, Julia Tilburg, Sharmistha Pal, Luis Francisco Zirnberger Batista, Joseph E. Italiano, Jr., Kellie R. Machlus
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2026-01-01
Serie:Blood Advances
Accesso online:http://www.sciencedirect.com/science/article/pii/S2473952925005749
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