Synergistic rheumatoid arthritis therapy by interrupting the detrimental feedback loop to orchestrate hypoxia M1 macrophage polarization using an enzyme-catalyzed nanoplatform

A detrimental feedback loop between hypoxia and oxidative stress consistently drives macrophage polarization toward a pro-inflammatory M1 phenotype, thus persistently aggravating rheumatoid arthritis (RA) progression. Herein, an enzyme-catalyzed nanoplatform with synergistic hypoxia-relieving and re...

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Bibliografische Detailangaben

Hauptverfasser:	Dong Guo, Hui Liu, Sheng Zhao, Xinya Lu, Haoyu Wan, Yitao Zhao, Xinzhi Liang, Anbiao Zhang, Mengyuan Wu, Zhisheng Xiao, Ning Hu, Zhong Li, Denghui Xie
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	KeAi Communications Co., Ltd. 2024-11-01
Schriftenreihe:	Bioactive Materials
Schlagworte:	Hypoxia Oxidative stress Nanoplatform Macrophage Metabolic regulation Rheumatoid arthritis
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2452199X24002974
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