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Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo

Abstract Background The cerebellum is the sensitive region of the brain to developmental abnormalities related to the effects of oxidative stresses. Abnormal cerebellar lobe formation, found in Jun dimerization protein 2 (Jdp2)-knockout (KO) mice, is related to increased antioxidant formation and a...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Chia-Chen Ku, Kenly Wuputra, Kohsuke Kato, Jia-Bin Pan, Chia-Pei Li, Ming-Ho Tsai, Michiya Noguchi, Yukio Nakamura, Chung-Jung Liu, Te-Fu Chan, Ming-Feng Hou, Shigeharu Wakana, Yang-Chang Wu, Chang-Shen Lin, Deng-Chyang Wu, Kazunari K. Yokoyama
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2021-06-01
Schriftenreihe:Stem Cell Research & Therapy
Schlagworte:
Antioxidation
Cerebellum
Granule cells
Jun dimerization protein 2 (Jdp2)
Reactive oxygen species (ROS)
Online-Zugang:https://doi.org/10.1186/s13287-021-02424-4
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