Direct Delivery of ANA-TA9, a Peptide Capable of Aβ Hydrolysis, to the Brain by Intranasal Administration

We have recently reported Catalytides (Catalytic peptides) JAL-TA9 (YKGSGFRMI) and ANA-TA9 (SKGQAYRMI), which are the first Catalytides found to cleave Aβ42. Although the Catalytides must be delivered to the brain parenchyma to treat Alzheimer’s disease, the blood–brain barrier (BBB) limits their en...

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Bibliografske podrobnosti

Principais autores:	Yusuke Hatakawa, Akiko Tanaka, Tomoyuki Furubayashi, Rina Nakamura, Motomi Konishi, Toshifumi Akizawa, Toshiyasu Sakane
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2021-10-01
Serija:	Pharmaceutics
Teme:	nasal application nose to brain olfactory pathway synthetic peptide Catalytide Alzheimer’s disease
Online dostop:	https://www.mdpi.com/1999-4923/13/10/1673
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